A comparison of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor).
نویسندگان
چکیده
A comparison has been made of the electrophoretic behavior, chemical composition, amino-terminal sequence, and immunological properties of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor). Some immunological crossreactivity was found between the antibody to prothrombin and factor X although prothrombin and factor X differ substantially in amino-acid and carbohydrate composition. Considerable amino-acid sequence homology was found in the amino-terminal portion of prothrombin, factor IX, and the light chain of factor X. These data provide further evidence to support the hypothesis that at least three of the vitamin K-dependent clotting factors have evolved from a common ancestral gene.
منابع مشابه
Preparation of factor VII concentrate using CNBr-activated
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 71 2 شماره
صفحات -
تاریخ انتشار 1974